![]() ![]() Fura-2 was used to assess changes in intracellular Ca 2+. Modulation of ion channels and changes in excitability were measured in the absence and presence of IMs (in μ m: 1 prostaglandin, 10 bradykinin, and 1 histamine) using whole-cell and perforated-patch recordings. Trigeminal ganglion neurons from adult female Sprague Dawley rats were acutely dissociated 10–14 d after application of retrograde tracer DiI onto the dura. Given the importance of inflammatory mediator (IM)-induced dural afferent sensitization to this pain syndrome, the present study was designed to identify ionic mechanisms underlying this process. Migraineurs experience debilitating headaches that result from neurogenic inflammation of the dura and subsequent sensitization of dural afferents.
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